Indiana Uplands is massive at 4,800 square miles. Located in south central Indiana, fully within the state. Modification to the existing Ohio River Valley AVA, decreasing its size by 1,530 square miles to eliminate the prospect of overlapping into Indiana Uplands.

Beginning at county lines between Morgan and Monroe Counties the AVA spans 110 miles south to the Ohio River and the boundary of Kentucky. 19 Indiana counties are all or in part included in the AVA. 19 vineyards covering roughly 200 acres are present along with 17 existing wineries. Jim Butler of Butler Winery in Bloomington IN submitted the petition for Indiana Uplands.

The AVA is best known to grow hybrid grapes such as Traminette, Vidal, Vignoles, Chambourcin, Cayuga and Catawba due to severe cold winter months.